Nope, all you do with super glue is pic a place to glue the frag. Then pat dry the frag part you will be applying the glue to. Also kinda toothbrush the place you will be glueing the frag to in the tank. Squeeze a glob on and place in tank where you picked out.
If you are glueing to a piece of rubble, dry it off also. Glue on and hold together in tank until glue sets.
Make sure you do not glue your fingers to the frag!
It takes practice.
With the epoxy, I just clean the area with a toothbrush, mix the epoxy, and epoxy the things I want. This takes practice also. There are so many ways to do it and so many things you can epoxy, from frags, coral, rock, ect...
I have been using both for years with no adverse effects. I epoxy my rock work together, frags down, corals down, I make frag plugs with it and so on. After a while it all gets encrusted or corallined over.