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Cure for STN / RTN...Finally!!! (2 Viewers)

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OP
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Found a few more interesting details and figured I’d share it hear as well.

A little more background on the Doc:

Hello Dr Deukmedjian here. I am a biologist. Double major in biochemistry/ cell biology and second degree in chemistry from UCSD. Second I studied at Scripps Institute of Oceanography at UCSD. I am not a “spine doc” I am a Neurosurgeon thank you. And Frankly I cant stand haters.
The parasites are the cause of ALL coral RTN and STN unless you do something like boil your coral in lye where they won’t be. But don’t believe me and keep spreading the infection.


Some new info that I found to be very interesting. I’m gonna PM this guy and pick his brain more.

In order to collaborate, the parasite Philaster lucinda is known to be sensitive to metronidazole in low concentration, with MIC (minimum inhibitory concentration) of the order of 1 mg / liter administered 12/12 hours for 6 days. Metronidazole is safe for fish, corals, crustaceans and the biological filter (at this concentration and up to 10 times higher), not reaching the nitrogen cycle and can be administered directly in the display tank without major consequences. However ... well-conducted eradication experiments of the parasite Philaster lucinda failed to halt the progression of RTN in corals, as demonstrated in the topic below:

Probable new approach in STN syndrome?

Regards
 
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My final conclusion in a long post debate:

-Philaster Lucinda-

In the metronidazole‐treated corals, we were also able to locate numerous rod‐shaped bacteria associated with these fragmented tissues. This may explain why previous studies have failed to find bacteria associated with WS lesions, “as infected tissues are “rapidly” consumed by the ciliates.”

From the pattern of disease progression and histopathology in relation to the selective elimination of microbial groups, we conclude that these ‘white’ diseases are a result of a nonspecific bacterial infection and a ‘secondary’ infection by the Philaster lucinda ciliate. Although we have not observed the initiation of infection, a nonspecific, multispecies bacterial infection appears to be a co-requirement for WS lesion progression and we hypothesize that the bacterial infection occurs initially, weakening the defenses of the host to predation by the ciliates.

Although The Philaster lucinda ciliate's "may not" be the 1st cause....they're certainly the most consistent agents with direct evidence for involvement in pathogenesis as it has been observed to consume "INTACT CORAL TISSUES.

White Syndrome in Acropora muricata: Nonspecific bacterial infection and ciliate histophagy

All these diseases are associated with the specific ciliate Philaster lucinda, and it remains the only agent with direct evidence for involvement in pathogenesis as it has been observed to consume intact coral tissues at the lesion interface (Sweet & Bythell 2012).

I'm not concerned about who started it anymore. It looks like the most damage (RTN) is done by the Philaster. Doesn't matter if they're the secondary infection.
 

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The r2r thread on this is eye-opening. After reading through it, it's hard to believe this man's (the doctor) credentials based on his behavior.
He flies off the handle at anyone asking for actual proof or evidence and makes statements of fact that are demonstrably untrue.
Snake oil confirmed Maybe not snake oil, but I certainly wouldn't give a single dollar to this person. :rolleyes:
 
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The r2r thread on this is eye-opening. After reading through it, it's hard to believe this man's (the doctor) credentials based on his behavior.
He flies off the handle at anyone asking for actual proof or evidence and makes statements of fact that are demonstrably true.
Snake oil confirmed Maybe not snake oil, but I certainly wouldn't give a single dollar to this person. :rolleyes:

Yeah, I’ll give anybody the benefit of doubt, but I have to follow logic and facts. He wouldn’t give more information about any of his claims. When questioned about it, he basically attacked the people asking. Testing of the “in-tank” treatment was proving more dangerous than beneficial and it wasn’t stopping RTN. He kept saying that a particular parasite was Uronema and you guys know how much I’ve hated Uronema and have done multiple autopsies on fish known to have it and the same parasite was present every time. I know what Uronema looks like. I called him out on it and posted several pictures of Uronema with the appropriate um size and cell structure. He ignored it and wouldn’t respond. Yet during all this he kept pushing his product on YouTube regardless of the facts that we were finding out after reading multiple studies. The facts basically contradicted his statements and his website. He left the thread and never returned to answer questions or deal with the discrepancies on his website. He tried to take credit for Mike Sweet’s work and the list goes on and on.

FWIW...the dip works fairly well, but so does 60ML of 3% “Equate” Hydrogen peroxide in 1 Liter of tank water for 2 minutes. This costs $5 vs $60
 
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This deserves a repost:

Yesterday at 3:25 PM
bblumberg
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Prime Coral said: ↑
Publishing in a peer reviewed journal is not the standard.
Publishing in a peer reviewed journal has only ONE requirement: the editor in chief decides to publish or not. Has NOTHING to do with peer comments, statistics, study design, or any of your assertions above. I have published my own peer reviewed papers and I am currently a peer reviewer for several scientific journals. There is far too much personal bias in the publication process and it ultimately has nothing to do with the actual science, whether it is good science or not.
You are 100% incorrect. As a research scientist, published author, peer reviewer, NIH funded principal investigator, neuroscientist, biochemist, cell biologist and chemist I can definitively tell you the peer review process is mostly a "boys club". I have no interest in participating in at this time.
Click to expand...
This is something that I cannot let pass without comment. What you say is almost 100% incorrect based on my experience as a working university scientist with many publications in the peer-reviewed literature (have a look at my site Blumberg lab home or search me on PubMed if you doubt this).

While there is a bit of a clubby nature to getting your papers reviewed in the most high impact journals in the field of biomedical sciences (Nature, Science, Cell Press journals). peer-review is the best way to ensure that the work published is of high quality. Your statement that publishing in a peer-reviewed journal "Has NOTHING to do with peer comments, statistics, study design, or any of your assertions above." is completely false and demonstrates that you have little idea about what the publication process entails.

Whether or not a paper is published in the peer-reviewed literature depends largely on the quality of the science. This includes study design, statistical analysis, peer reviewer comments and, ultimately, the approval of the editorial board of the journal (typically an Associate Editor). High quality science will always be published in some reputable journal, irrespective of how controversial the topic may be. Which peer-reviewed journal it is published in depends on the overall interest and impact of the research. Work of high impact and widespread interest to multiple fields gets published in high-impact journals. High quality work of more limited interest gets published in specialist journals.

Having said that, the peer-review process is not perfect. Sometimes peer-reviewers are lazy and allow sloppy science to slip through. This most often happens at low-impact journals, but it happens. Sometimes reviewers are biased and inappropriately reject good work but this will get published in an other journal if it is scientifically sound. Sometimes authors fake or misrepresent results allowing bad science to get published. This is largely discovered eventually and the perpetrators punished.

Sometimes there are so-called peer-reviewed journals that are not. Rather they pretend to be so, but are basically pay the fee and you will be published. You can read about this problem here, among other places"
https://retractionwatch.com/2013/10...poofs-hundreds-of-journals-with-a-fake-paper/

The bottom line is that peer-review largely works, both for publications and for research grants. It could be improved. What couldn't?

I can easily imagine why you do not want to publish your putative RTN/STN cure in the peer-reviewed literature. This is because you would need to disclose what actual chemicals it contains so that other interested scientists could duplicate your work. This is at the heart of science - it must be reproducible in order to be believed. This is not the same thing as me buying your treatment and testing it in my tanks at home.

Lastly, since you have described yourself as "a research scientist, published author, peer reviewer, NIH funded principal investigator, neuroscientist, biochemist, cell biologist and chemist" I thought that I'd give that a quick fact check. According to your Facebook Ara Deukmedjian
and LinkedIn
https://www.linkedin.com/in/ara-deukmedjian-md-faans-931910167/
pages, Dr. Ara J. Deukmedjian graduated from UCSD with a degree in Cell Biology and Biochemistry in 1993, received an MD from USC in 1997 and has been a working neurosurgeon since that time.

I found 4 publications for Ara Deukmedjian in the peer-reviewed literature, 3 on surgical techniques and 1 on cortical injury (presumably from your postdoctoral studies). If there are others, they are not in journals indexed on PubMed.

As for your being an NIH funded principal investigator, a quick search of NIH Reporter Query Form - NIH RePORTER - NIH Research Portfolio Online Reporting Tools Expenditures and Results for your last name (to avoid missing any) turn up only an F32 award in 2000-2002 on "Interactions between heterotopic and dysplastic cortex". For those who do not know, an F32 award is an individual postdoctoral fellowship (i.e., a mentored training award). Most researchers would only use the term "NIH-funded principal investigator" for recipients of NIH R- U, or P-series awards Types of Grant Programs | grants.nih.gov
F, K and T-series awards are mentored training awards and the awardees are not properly called NIH-funded principal investigators so your classification of the F32 award in this way is a stretch.

Nothing I said above confirms or refutes your acquired expertise in marine biology or the quality of Prime Coral's putative STN/RTN cure. Whether or not this stuff works will be tested over time as people buy it and test its effectiveness. However, I have found over the years that it is better to stick closely to the demonstrable facts if you want people to believe your statements. In my opinion, much of what you said in the above post is "stretching the facts" and that is viewing them in the most favorable light.
 
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